Experimental modeling of myocardial infarction in old rats

The results of modeling acute myocardial infarction on 20 male Wistar rats aged 24 months are presented. Ischemic effect is carried out by local injection 1.5% sclerosant ethoxysclerol (0.25 ml) into the thickness myocardium under general anesthesia using non-traumatic needle with silicone coating, which allows to simulate minimal invasive animal's body, trauma, little duration intervention, low mortality, frequency complications and absence systemic action drugs.